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KMID : 0356919950290040546
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Korean Journal of Anesthesiology
1995 Volume.29 No. 4 p.546 ~ p.551
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Analgesic Effects of Epidural Bupivacaine, Alone or in Combination with Clonidine on Pain after Cesarean Section
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이성우
박병순/김정호/강훈수
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Abstract
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Epidural clonidine produces analgesia via non-opioid mechanism and it may be used as an adju-vant to local anesthetics in obstetric analgesia.
To evaluate the effects of epidural clonidine and bupivacaine for post-cesarean section analgesia, we designed a double-blind study. Sixty patients scheduled for elective cesarean section were divided into three groups. Group 1 (n=20) received
0.125%
bupivacaine 2 ml/hour epidurally for 2 days. Group 2 (n-20) received 150 ㎍ clonidine bolus, followed by 0.125% bupivacaine 2 ml/hour and clonidine 10 ㎍hour for 2 days. Group 3 (n=20) received 150㎍ clonidine bolus, followed by 0.125%
bupivacaine
2ml/hour and clonidine 20㎍hour for 2 days.
At the end of the cesarean section, above drug was administered epidurally. Postoperative analgesia was assessed by recording VAS(visual analogue scales) at 1, 2, 4, 8, 16, 32, and 48 postoperative hours. Sedation score, heart rate and systolic
and
diastolic blood pressure were also checked.
@ES The results were as follows.
@EN 1) VAS were significantly decreased in group 2 at 1∼16 hours and in group 3 at 1∼32 hours compared with group 1. They were decreased in group 3 compared with group 2 at 1∼48 hours but no significance was seen between two groups.
2) The changes of systolic and diastolic blood pressures & sedation scores were not significantly different between any two groups.
In summary, co-administration of clonidine and bupivacaine epidurally provided more profound analgesia compared with bupivacaine alone after cesarean section. (Korean J Anesthesiol 1995; 29: 546∼551)
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